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USC-OGP 2-DE database

Two-dimensional polyacrylamide gel electrophoresis database


USC-OGP 2-DE database 
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Searching in 'USC-OGP 2-DE database' for entry matching: Q13177




USC-OGP 2-DE database:  Q13177


Q13177


General information about the entry
View entry in simple text format
Entry namePAK2_HUMAN
Primary accession numberQ13177
integrated into USC-OGP 2-DE database on January 17, 2017 (release 1)
2D Annotations were last modified onJanuary 17, 2017 (version 1)
General Annotations were last modified on April 5, 2017 (version 2)
Name and origin of the protein
DescriptionRecName: Full=Serine/threonine-protein kinase PAK 2; EC=2.7.11.1; AltName: Full=Gamma-PAK; AltName: Full=PAK65; AltName: Full=S6/H4 kinase; AltName: Full=p21-activated kinase 2; Short=PAK-2; AltName: Full=p58; Contains: RecName: Full=PAK-2p27; Short=p27; Contains: RecName: Full=PAK-2p34; Short=p34; AltName: Full=C-t-PAK2;.
Gene nameName=PAK2
Annotated speciesHomo sapiens (Human) [TaxID: 9606]
TaxonomyEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
References
[1]   2D GEL CHARACTERIZATION
Author 1., Author 2.
Submitted (Mar-2011) to Current
2D PAGE maps for identified proteins
How to interpret a protein

PLATELET_4-7 {PLATELET 4-7}
Homo sapiens (Human)
PLATELET_4-7
  map experimental info
 
PLATELET_4-7

MAP LOCATIONS:
pI=5.58; Mw=60151



UVEAL_MELANOMA_3-10 {UVEAL MELANOMA 3-10}
Homo sapiens (Human)
UVEAL_MELANOMA_3-10
  map experimental info
 
UVEAL_MELANOMA_3-10

MAP LOCATIONS:
pI=5.70; Mw=62554
pI=5.84; Mw=62554

Cross-references
UniProtKB/Swiss-ProtQ13177; PAK2_HUMAN.



2D PAGE maps for identified proteins
  • How to interpret a protein map
  • You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw.
  • Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly.
  • Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed.



External data extracted from UniProtKB/Swiss-Prot
Extracted from UniProtKB/Swiss-Prot, release: 0.0
Entry namePAK2_HUMAN
Primary accession numberQ13177
Secondary accession number(s) Q13154 Q6ISC3
Sequence was last modified on April 3, 2007 (version 3)
Annotations were last modified on March 15, 2017 (version 185)
Name and origin of the protein
DescriptionRecName: Full=Serine/threonine-protein kinase PAK 2; EC=2.7.11.1; AltName: Full=Gamma-PAK; AltName: Full=PAK65; AltName: Full=S6/H4 kinase; AltName: Full=p21-activated kinase 2; Short=PAK-2; AltName: Full=p58; Contains: RecName: Full=PAK-2p27; Short=p27; Contains: RecName: Full=PAK-2p34; Short=p34; AltName: Full=C-t-PAK2;
Gene nameName=PAK2
Encoded onName=PAK2
Keywords3D-structure; Acetylation; Allosteric enzyme; Apoptosis; ATP-binding; Complete proteome; Cytoplasm; Direct protein sequencing; Growth regulation; Host-virus interaction; Kinase; Lipoprotein; Membrane; Myristate; Nucleotide-binding; Nucleus; Phosphoprotein; Reference proteome; Serine/threonine-protein kinase; Transferase; Ubl conjugation.
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License
Cross-references
EMBLU24153; AAA65442.1; -; mRNA
EMBLBC069613; AAH69613.1; -; mRNA
EMBLU25975; AAA75468.1; -; mRNA
CCDSCCDS3321.1; -; .
PIRS58682; S58682; .
RefSeqNP_002568.2; NM_002577.4; .
RefSeqXP_011511172.1; XM_011512870.2; .
RefSeqXP_016861990.1; XM_017006501.1; .
UniGeneHs.518530; -; .
PDB3PCS; X-ray; 2.86 A; E/F/G/H=121-136
PDBsum3PCS; -; .
ProteinModelPortalQ13177; -; .
SMRQ13177; -; .
BioGrid111098; 84; .
DIPDIP-38249N; -; .
IntActQ13177; 47; .
MINTMINT-235655; -; .
STRING9606.ENSP00000314067; -; .
BindingDBQ13177; -; .
ChEMBLCHEMBL4487; -; .
GuidetoPHARMACOLOGY2134; -; .
iPTMnetQ13177; -; .
PhosphoSitePlusQ13177; -; .
SwissPalmQ13177; -; .
BioMutaPAK2; -; .
DMDM143811432; -; .
OGPQ13177; -; .
EPDQ13177; -; .
MaxQBQ13177; -; .
PaxDbQ13177; -; .
PeptideAtlasQ13177; -; .
PRIDEQ13177; -; .
DNASU5062; -; .
EnsemblENST00000327134; ENSP00000314067; ENSG00000180370; .
GeneID5062; -; .
KEGGhsa:5062; -; .
UCSCuc003fwy.4; human; .
CTD5062; -; .
DisGeNET5062; -; .
GeneCardsPAK2; -; .
H-InvDBHIX0030815; -; .
HGNCHGNC:8591; PAK2; .
HPACAB007794; -; .
MIM605022; gene; .
neXtProtNX_Q13177; -; .
OpenTargetsENSG00000180370; -; .
PharmGKBPA32918; -; .
eggNOGKOG0578; Eukaryota; .
eggNOGENOG410XP4K; LUCA; .
GeneTreeENSGT00860000133680; -; .
HOGENOMHOG000234202; -; .
HOVERGENHBG108518; -; .
InParanoidQ13177; -; .
KOK04410; -; .
OMAMTSASHK; -; .
OrthoDBEOG091G04H8; -; .
PhylomeDBQ13177; -; .
TreeFamTF105351; -; .
BRENDA2.7.11.1; 2681; .
ReactomeR-HSA-164944; Nef and signal transduction; .
ReactomeR-HSA-202433; Generation of second messenger molecules; .
ReactomeR-HSA-211728; Regulation of PAK-2p34 activity by PS-GAP/RHG10; .
ReactomeR-HSA-211733; Regulation of activated PAK-2p34 by proteasome mediated degradation; .
ReactomeR-HSA-211736; Stimulation of the cell death response by PAK-2p34; .
ReactomeR-HSA-2871796; FCERI mediated MAPK activation; .
ReactomeR-HSA-389359; CD28 dependent Vav1 pathway; .
ReactomeR-HSA-3928664; Ephrin signaling; .
ReactomeR-HSA-399954; Sema3A PAK dependent Axon repulsion; .
ReactomeR-HSA-428540; Activation of Rac; .
ReactomeR-HSA-4420097; VEGFA-VEGFR2 Pathway; .
ReactomeR-HSA-5218920; VEGFR2 mediated vascular permeability; .
ReactomeR-HSA-5621575; CD209 (DC-SIGN) signaling; .
ReactomeR-HSA-5627123; RHO GTPases activate PAKs; .
ReactomeR-HSA-5687128; MAPK6/MAPK4 signaling; .
SignaLinkQ13177; -; .
SIGNORQ13177; -; .
ChiTaRSPAK2; human; .
EvolutionaryTraceQ13177; -; .
GeneWikiPAK2; -; .
GenomeRNAi5062; -; .
PMAP-CutDBQ13177; -; .
PROPR:Q13177; -; .
ProteomesUP000005640; Chromosome 3; .
BgeeENSG00000180370; -; .
CleanExHS_PAK2; -; .
ExpressionAtlasQ13177; baseline and differential; .
GenevisibleQ13177; HS; .
GOGO:0005737; C:cytoplasm; IDA:BHF-UCL; .
GOGO:0005829; C:cytosol; TAS:Reactome; .
GOGO:0005634; C:nucleus; IEA:UniProtKB-SubCell; .
GOGO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell; .
GOGO:0005886; C:plasma membrane; TAS:Reactome; .
GOGO:0005524; F:ATP binding; IEA:UniProtKB-KW; .
GOGO:0045296; F:cadherin binding; IDA:BHF-UCL; .
GOGO:0042802; F:identical protein binding; IPI:IntAct; .
GOGO:0004672; F:protein kinase activity; TAS:ProtInc; .
GOGO:0019901; F:protein kinase binding; IPI:BHF-UCL; .
GOGO:0004674; F:protein serine/threonine kinase activity; IDA:BHF-UCL; .
GOGO:0030296; F:protein tyrosine kinase activator activity; IDA:BHF-UCL; .
GOGO:0004702; F:signal transducer; downstream of receptor; with serine/threonine kinase activity
IBA:GO_Central.
GOGO:0006915; P:apoptotic process; IEA:UniProtKB-KW; .
GOGO:0071407; P:cellular response to organic cyclic compound; IEA:Ensembl; .
GOGO:0060996; P:dendritic spine development; IEA:Ensembl; .
GOGO:0038095; P:Fc-epsilon receptor signaling pathway; TAS:Reactome; .
GOGO:0043066; P:negative regulation of apoptotic process; IMP:UniProtKB; .
GOGO:2001271; P:negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis; IDA:UniProtKB; .
GOGO:0006469; P:negative regulation of protein kinase activity; TAS:ProtInc; .
GOGO:0018105; P:peptidyl-serine phosphorylation; IDA:BHF-UCL; .
GOGO:0016310; P:phosphorylation; IDA:UniProtKB; .
GOGO:2001238; P:positive regulation of extrinsic apoptotic signaling pathway; IMP:UniProtKB; .
GOGO:0050731; P:positive regulation of peptidyl-tyrosine phosphorylation; IDA:BHF-UCL; .
GOGO:0046777; P:protein autophosphorylation; IDA:MGI; .
GOGO:0006468; P:protein phosphorylation; IDA:MGI; .
GOGO:0050690; P:regulation of defense response to virus by virus; TAS:Reactome; .
GOGO:0040008; P:regulation of growth; IEA:UniProtKB-KW; .
GOGO:0007165; P:signal transduction; TAS:ProtInc; .
GOGO:0002223; P:stimulatory C-type lectin receptor signaling pathway; TAS:Reactome; .
GOGO:0031295; P:T cell costimulation; TAS:Reactome; .
GOGO:0050852; P:T cell receptor signaling pathway; TAS:Reactome; .
GOGO:0048010; P:vascular endothelial growth factor receptor signaling pathway; TAS:Reactome; .
GOGO:0016032; P:viral process; IEA:UniProtKB-KW; .
CDDcd01093; CRIB_PAK_like; 1; .
Gene3D3.90.810.10; -; 1; .
InterProIPR000095; CRIB_dom; .
InterProIPR011009; Kinase-like_dom; .
InterProIPR033923; PAK_BD; .
InterProIPR000719; Prot_kinase_dom; .
InterProIPR017441; Protein_kinase_ATP_BS; .
InterProIPR008271; Ser/Thr_kinase_AS; .
PfamPF00786; PBD; 1; .
PfamPF00069; Pkinase; 1; .
SMARTSM00285; PBD; 1; .
SMARTSM00220; S_TKc; 1; .
SUPFAMSSF56112; SSF56112; 1; .
PROSITEPS50108; CRIB; 1; .
PROSITEPS00107; PROTEIN_KINASE_ATP; 1; .
PROSITEPS50011; PROTEIN_KINASE_DOM; 1; .
PROSITEPS00108; PROTEIN_KINASE_ST; 1; .



USC-OGP 2-DE database image


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Database constructed and maintained by Angel Garcia, using the Make2D-DB II package (ver. 3.10.2) from the World-2DPAGE Constellation of the ExPASy web server

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